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【莫德納mRNA前瞻新創獎-系列專訪05】- 清大化工團隊研發口服疫苗 β-葡聚糖有望助核酸疫苗藥物突破生物屏障

【莫德納mRNA前瞻新創獎-系列專訪05】- 清大化工團隊研發口服疫苗 β-葡聚糖有望助核酸疫苗藥物突破生物屏障

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Welcome

 

Welcome to Biomaterials Laboratory for Tissue Engineering and Drug/Gene Delivery in National Tsing Hua University. Our main research interests are in biomaterials that can be applied to tissue engineering, drug delivery, and blood substitute. Additionally, we have been focusing on developing nano-scale drug-delivery carriers and tissue-engineering scaffolds.
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UPCOMING EVENTS
International Advanced Drug Delivery Symposium  (2024 IADDS )
​2024/8/15-2024/8/16
Secleted Publications

2024

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  1. Van Khanh Nguyen, Nhien Nguyen, Zhe-Cheng Li, Chao-Min Cheng, Jui-To Wang, Yu-Wei Chiang, Hsiang-Lin Song, Shih-Kai Lo, Cam Hoa Mac, Yen Chang, Wei-Tso Chia*, and Hsing-Wen Sung* “Inflammation-Activated Endogenous Macrophage-Mediated Prodrug Delivery System Overcoming Biological Barriers for Enhanced Oral Meningitis Therapy” Advanced Functional Materials,2024. (Accepted)

  2. Cam-Hoa Mac, Hsien-Meng Tai, Sheng-Min Huang, Hsu-Hsia Peng, Amit Kumar Sharma, Giang Le Thi Nguyen, Pei-Ju Chang, Jui-To Wang, Yen Chang, Yu-Jung Lin, Hsing-Wen Sung*, ”Orally Ingested Self-Powered Stimulators for Targeted Gut–Brain Axis Electrostimulation to Treat Obesity and Metabolic Disorders”, Advanced Materials, 202310351, 2024. (SCI IF 29.4)

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2023

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  1. Putry Yosefa Siboro+, Amit Kumar Sharma+, Pei-Jhun Lai, Jayachandran Jayakumar, Fwu-Long Mi, Hsin-Lung Chen, Yen Chang*,Hsing-Wen Sung*, "Harnessing HfO2 Nanoparticles for Wearable Tumor Monitoring and Sonodynamic Therapy in Advancing Cancer Care" ACS Nano, 2485–2499,2023. (SCI IF 17.1)

  2. Cam-Hoa Mac, Hsien-Meng Tai, Sheng-Min Huang, Hsu-Hsia Peng, Amit Kumar Sharma, Giang Le Thi Nguyen, Pei-Ju Chang, Jui-To Wang, Yen Chang, Yu-Jung Lin, Hsing-Wen Sung*, ”Orally Ingested Self-Powered Stimulators for Targeted Gut–Brain Axis Electrostimulation to Treat Obesity and Metabolic Disorders”, Advanced Materials, 2023. Revision under Review (SCI IF 29.4)

  3. Cheng-Yu Wu+, Cam-Hoa Mac+, Tung-Han Yang+, Khanh Nguyen, Shih-Kai Lo, Yen Chang, Po-Liang Lai, Hsing-Wen Sung*, Yu-Jung Lin*,” Nanoscale Photocatalytic Hydrogen Production System Mitigates Inflammation by Harnessing Glycolysis Waste”, Chemical Engineering Journal, Volume 476,146614, 2023. (SCI IF 15.1)

  4. Yu-Jung Lin, Po-Kai Luo, Huei-Rou Su, Hung-Yun Lu, Wan-An Chang, Min-Chun Chiang, Hsin-Lung Chen, Kai Chen, Hao-Ji Wei*, Kun-Ju Lin*, Sung, H. W.*, ”A Low-Energy Emulsification Platform Based on a Diet Coke–Mentos Reaction-Derived Bubbly Flow for Formulating Various Emulsions as Drug Carriers”, Biomaterials,122264, 2023 (SCI IF 14.0)

  5. Kuan-Hung Chen, Tun-Yu Huang, Nhien Nguyen, Yu-Tzu Yu, Yu-Jung Lin, Hsiang-Lin Song, Jui-To Wang, Hsin-Lung Chen, Sung, H. W.* “Macrophage-Hitchhiked Orally Administered β-Glucans-Functionalized Nanoparticles as “Precision-Guided Stealth Missiles” for Targeted Pancreatic Cancer Therapy” Advanced Materials, 2304735. (2023 June) (SCI IF 29.4)

  6. Chih-Wei Chou, Wei-Tso Chia, Cam-Hoa Mac, Cheng-Yu Wu, Chun-Chieh Chen, Hsiang-Lin Song, Yi-Hsuan Lin, Yu-Jung Lin*, and Sung, H. W.*, “Selective Accumulation of Ionic Nanocrystal H2 Storage System as an In Situ H2/Boric Acid Nanogenerator Fights against Ethanol-Induced Gastric Ulcers“ ,Chemical Engineering J, Volume 463, 142373. (2023 May) (SCI IF 15.1)

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2022

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  1. Zhang, Y. C., Wang, M. Y., Zhang, C. Y., Fan, Y. F., Wu, J., Li, S. H., ... Sung, H. W*& Li, R. K. (2022 Nov.). Epicardial delivery of a conductive membrane synchronizes conduction to reduce atrial fibrillation. Journal of Controlled Release, 351, 847-859.(11.467)

  2. Siboro, P. Y., Nguyen, V. K. T., Miao, Y. B., Sharma, A. K., Mi, F. L., Chen, H. L., ... & Sung, H. W* (2022 Aug). Ultrasound-Activated, Tumor-Specific In Situ Synthesis of a Chemotherapeutic Agent Using ZIF-8 Nanoreactors for Precision Cancer Therapy. ACS Nano, 16(8), 12403-12414. (IF 18.072)

  3. Mac, C. H., Chan, H. Y., Lin, Y. H., Sharma, A. K., Song, H. L., Chan, Y. S., Lin,K.J., Lin,Y.J., Sung, H. W* (2022 May.) “Engineering a biomimetic bone scaffold that can regulate redox homeostasis and promote osteogenesis to repair large bone defects” Biomaterials, 286, 121574. (IF 15.304)

  4. Nguyen, N., Lin, Z. H., Barman, S. R., Korupalli, C., Cheng, J. Y., Song, N. X., Chang,Y., Mi,F.-L.,  Song,H.-L., Sung, H. W*., Lin,Y. J*. (2022 May.)“Engineering an Integrated Electroactive Dressing to Accelerate Wound Healing and Monitor Noninvasively Progress of Healing. “Nano Energy, 107393. (IF: 17.881)

 

2021

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  1. Miao, Y. B., Lin, Y. J., Chen, K. H., Luo, P. K., Chuang, S. H., Yu, Y. T., Tai, H. M., Chen, C. T., Lin, K. J., Sung, H. W.*, “Engineering Nano- and Microparticles as Oral Delivery Vehicles to Promote Intestinal Lymphatic Drug Transport” Advanced Materials, 2104139, 2021. (SCI 30.85)

  2. Korupalli, C., Li, H., Nguyen, N., Mi, F. L., Chang, Y., Lin, Y. J.*, Sung, H. W.*, “Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives” Advanced Healthcare Materials, 10(6), 2001384, 2021. (SCI 9.933)

  3. Miao, Y. B., Chen, K. H., Chen, C. T., Mi, F. L., Lin, Y. J., Chang, Y., Chiang, C.S., Wang, J.T., Lin,K.J., Sung, H. W.* ,“ A noninvasive gut-to-brain oral drug delivery system for Treating Brain Tumors” Advanced Materials, 2100701, 2021(July ). (SCI 30.849)

  4. Chen, P.-M., Pan, W.-Y.,Luo, P.-K.,Phung, H.-N., Liu, Y.-M., Chiang, M.-C., Chang, W.-A., Tien, T.-L., Huang, C.-Y., Wu, W.-W., Chia, W.-T.*, Sung, H.W*,“Pollen-Mimetic Metal–Organic Frameworks with Tunable Spike-Like Nanostructures That Promote Cell Interactions to Improve Antigen-Specific Humoral Immunity” ACS Nano, vol.15, pp.5775-7836, 2021. (SCI 15.881)

  5. Hsieh,M.H., Wei,H.J., Chen,K.H., Wang,H.C., Yu,C.H., Lu,T.H., Chang,Y.*, Sung, H.W*,“A fast and facile platform for fabricating phase-change materials-based drug carriers powered by chemical Marangoni effect” Biomaterials, vol.271, pp. 120748, 2021. (SCI 12.497)

  6. An, Z., Wu, J., Li, S.H., Chen, S., Lu, F.L., Xu, Z.Y., Sung, H.W, Li, R.K.,“Injectable Conductive Hydrogel Can Reduce Pacing Threshold and Enhance Efficacy of Cardiac Pacemaker” Theranostics, vol.11(8), pp3948-3960, 2021. (SCI 11.556)

 

2020

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  1. Korupalli, C., Li, H., Nguyen, N., Mi, F. L., Chang,Y., Lin,Y.J.*, Sung, H.W*,“Conductive Materials for Healing Wounds: Their Incorporation in Electroactive Wound Dressings, Characterization, and Perspectives” Advanced Healthcare Materials, pp2001384, 2020. (SCI 8.78)

  2. Chen, P. M., Pan, W. Y., Miao, Y. B., Liu, Y. M., Luo, P. K., Phung, H. N., Wu, W.W., Ting, Y.-H., Yeh, C.-Y., Chiang, M.-C., Chia,W.-T*., Sung, H.W*,“Bioinspired engineering of a bacterium-like metal-organic framework for cancer immunotherapy” Advanced Functional Materials, pp 2003764, 2020. (SCI 18.808)

  3. He, S., Wu, J., Li, S.H., Wang, L., Sun, Y., Xie, J.; Ramnath, D., Weisel, Richard D., Yau, Terrence M., Sung, H.W; Li, R.K., “The conductive function of biopolymer corrects myocardial scar conduction blockage and resynchronizes contraction to prevent heart failure,” Biomaterials, vol.3, pp. 120285, 2020. (SCI 11.59) 

  4. Chen, K. H., Miao, Y. B., Shang, C. Y., Huang, T. Y., Yu, Y. T., Yeh, C. N., Song, H. L., Chen,C.T., Mi, F. L. , Lin, K. J., Sung, H.W*. ,“A bubble bursting-mediated oral drug delivery system that enables concurrent delivery of lipophilic and hydrophilic chemotherapeutics for treating pancreatic tumors in rats,” Biomaterials, vol.255, pp. 120157, 2020. (SCI 11.59) 

  5. Lin, Y.J., Chen, C.C., Dang N., Su, H.R., Lin, K.J., Chen, H.L., Hu, Y.J., Lai, P.L., Sung, H.W*. ,“Biomimetic Engineering of a Scavenger-Free Nitric Oxide-Generating/Delivering System to Enhance Radiation Therapy,” Small, vol 16, pp.2070126, 2020. (SCI 13.281) 

  6. Chen, S., Hsieh, M.H., Li, S.H., Wu, J., Weisel, R.D., Chang, Y., Sung, H.W.*, Li, R.K.* , “A Conductive Cell-Delivery Construct as a Bioengineered Patch that Can Improve Electrical Propagation and Synchronize Cardiomyocyte Contraction for Heart Repair,” Journal of Controlled Release, vol.320, pp.73-82, 2020. (SCI 8.66) 

  7. Wan, W.L., Tian, B. Lin, Y.J., Korupalli, C., Lu, M.Y., Cui, Q., Wan, D.H., Chang, Y.*, Sung, H.W.*, “Photosynthesis-Inspired H2 Generation Using a Chlorophyll-Loaded Liposomal Nanoplatform to Detect and Scavenge Excess ROS,” Nature Communications, vol.11, pp.534, 2020. (SCI 14.919) 

 

2019

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  1. Zhang, C., Hsieh, M. H., Wu, S. Y., Li, S. H., Wu, J., Liu, S.M., Wei, H.J., Weisel, R.D., Sung, H.W.*, Li, R.K.*, “A self-doping conductive polymer hydrogel that can restore electrical impulse propagation at myocardial infarct to prevent cardiac arrhythmia and preserve ventricular function,” Biomaterials, vol.231, pp. 119672, 2019. (SCI 11.59) 

  2. Cui, Q., Le, T. H., Lin, Y. J., Miao, Y. B., Sung, I. T., Tsai, W. B., Chan, H.Y., Lin, Z.H.*, Sung, H. W.*, “A self-powered battery-driven drug delivery device that can function as a micromotor and galvanically actuate localized payload release,” Nano Energy, vol.66, pp. 104120, 2019. (SCI 16.88) 

  3. Miao, Y.B., Pan, W.Y., Chen, K.H., Wei, H.J., Mi, F.L., Lu, M.Y., Chang, Y.*, Sung, H.W.*, “Engineering a Nanoscale Al‐MOF‐Armored Antigen Carried by a “Trojan Horse”‐Like Platform for Oral Vaccination to Induce Potent and Long‐Lasting Immunity,” Advanced Functional Materials, vol.29, pp. 1904828, 2019. (SCI 18.808)

  4. Hsieh, M.H., Tsai, H.W., Lin, K.J., Wu, Z.Y., Hu, H.Y., Chang, Y., Wei, H.J.*, Sung, H.W.*, “An in situ slow-releasing H2S donor depot with long-term therapeutic effects for treating ischemic diseases,” Materials Science and Engineering:C, vol.104, pp. 109954, 2019 (SCI 7.06)

  5. Chen, P.M., Pan, W.Y., Wu, C.Y., Yeh, C.Y., Korupalli, C., Luo, P.K., Chou, C.J., Chia, W.T.*, Sung, H.W.*, “Modulation of tumor microenvironment using a TLR-7/8 agonist-loaded nanoparticle system that exerts low-temperature hyperthermia and immunotherapy for in situ cancer vaccination,” Biomaterials, vol.15, pp. 119629, 2019. (SCI 11.59) 

  6. Korupalli, C., Pan, W.-Y., Yeh, C.-Y., Chen, P.-M., Mi, F.-L., Tsai, H.-W., Chang, Y., Wei, H.-J.*, Sung, H.-W.*, “Single-injecting, bioinspired nanocomposite hydrogel that can recruit host immune cells in situ to elicit potent and long-lasting humoral immune responses,” Biomaterials, vol. 216, pp. 119268, 2019. (SCI 11.59) 

  7. Lin, P.-Y., Chen, K.-H., Miao, Y.-B., Chen, H.-L., Lin, K.-J., Chen, C.-T., Yeh, C.‐N., Chang, Y.*, Sung, H.-W.*, “Phase‐Changeable Nanoemulsions for Oral Delivery of a Therapeutic Peptide: Toward Targeting the Pancreas for Antidiabetic Treatments Using Lymphatic Transport,” Advanced Functional Materials, vol.29, pp. 1809015, 2019. (SCI 18.808)

2018

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  1. Lin, Y.-J., Mi, F.-L., Lin, P.-Y., Miao, Y.-B., Huang, T., Chen, K.-H., Chen, C.-T., Chang, Y.*, Sung, H.-W.*, “Strategies for improving diabetic therapy via alternative administration routes that involve stimuli-responsive insulin-delivering systems,” Advanced Drug Delivery Reviews, vol. 139, pp. 71-82, 2018. (SCI 13.300) 

  2. Lin, W.-C., Pan, W.-Y., Liu, C.-K., Huang, W.-X., Song, H.-L., Chang, K.-S., Li, M.-J.*, Sung, H.-W.* “ In situ self-spray coating system that can uniformly disperse a poorly water-soluble H2S donor on the colorectal surface to treat inflammatory bowel diseases,” Biomaterials, vol. 182, pp. 289-298, 2018. (SCI 11.59) 

  3. Lin, P.-Y., Chiu, Y.-L., Huang, J.-H., Chuang, E.-Y., Mi, F.-L., Lin, K.-J., Juang, J.-H., Sung, H.-W.*, Leong, K. W.*, “Oral Nonviral Gene Delivery for Chronic Protein Replacement Therapy,” Advanced Science. vol.5, 1701079, 2018. (SCI 16.806) 

  4. Wan, W.-L., Lin, Y.-J., Shih, P.-C., Bow, Y.-R., Cui, Q., Chang, Y., Chia, W.-T.*, Sung, H.-W.*,” An In Situ Depot for Continuous Evolution of Gaseous H2 Mediated by a Magnesium Passivation/Activation Cycle for Treating Osteoarthritis,” Angew Chem Int Ed Engl. vol. 57, pp. 9875-9879, 2018. (SCI 15.336)

  5. Chuang, E.-Y.+, Lin, K.-J.+, Huang, T.-Y., Chen, H.-L., Miao, Y.-B., Lin, P.-Y., Chen, C.-T., Juang, J.-H*, Sung, H.-W.*, An Intestinal “Transformers”-Like Nanocarrier System for Enhancing the Oral Bioavailability of Poorly Water-Soluble Drugs, ACS Nano. vol.12, pp. 6389-6397, 2018. (SCI 15.881)

  6. Lin, Y.-J.+, Chen, C.-C.+, Chi, N.-W., Nguyen, T., Lu, H.-Y., Nguyen, D., Lai, P.-L.*, Sung, H.-W.*, “In situ self-assembling micellar depots that can actively trap and passively release NO with long-lasting activity to reverse osteoporosis,” Advanced Materials. vol.30, 1705605, 2018. (SCI 30.849) 

  7. Cui, Z., Ni, N.-C., Wu, J., Du, G.-Q., He, S., Yau, T.-M., Weisel, R.-D., Sung, H.-W., Li, R.-K.* “Polypyrrole-Chitosan Conductive Biomaterial Synchronizes Cardiomyocytes Contraction and Improves Myocardial Electrical Impulse Propagation,” Theranostics. vol. 8, pp. 2752–2764, 2018. (SCI 11.556) 

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2017

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  1. Lin, W.-C., Huang, C.-C., Lin, S.-J., Li, M.-J., Chang, Y., Lin, Y.-J., Wan W.-L., Shih, P.-C., Sung, H.-W.*, “In situ depot comprising phase-change materials that can sustainably release a gasotransmitter H2S to treat diabetic wounds,” Biomaterials, vol. 145, pp.1–8, 2017. (SCI  11.59) 

  2. Wan, W.-L., Lin, Y.-J., Chen, H.-L., Huang, C.-C., Shih, P.-C., Bow, Y.-R., Chia, W.-T.*, Sung, H.-W.* "In Situ Nanoreactor for Photosynthesizing H2 Gas to Mitigate Oxidative Stress in Tissue Inflammation," Journal of the American Chemical Society, vol. 139, pp. 12923-12926, 2017. (SCI 15.419) 

  3. Lin, P.-Y., Chuang, E.-Y., Chiu, Y.-H., Chen, H.-L., Lin, K.-J., Juang, J.-H., Chiang, C.-H., Mi, F.-L.*, Sung, H.-W.* “Safety and efficacy of self-assembling bubble carriers stabilized with sodium dodecyl sulfate for oral delivery of therapeutic proteins,” Journal of Controlled Release, vol. 256, pp. 168-175, 2017. (SCI 8.66)

  4. Lin, Y.-J., Huang, C.-C., Wan W.-L., Chiang, C.-H., Chang, Y., Sung, H.-W.*, “Recent advances in CO2 bubble-generating carrier systems for localized controlled release,” Biomaterials, vol. 133, pp. 154–164, 2017. (SCI 11.59) 

  5. Pelaz, B., Alexiou, C., Puebla, R.A.A., Alves, F., Andrews, A.M., Ashraf, S., …, Sung, H.-W., …, Parak, W.J.*, “Diverse Applications of Nanomedicine,” ACS Nano, vol. 11, pp. 2313–2381, 2017. (SCI 15.881)

  6. Korupalli, C., Huang, C.-C., Lin, W.-C., Pan, W.-Y., Lin, P.-Y., Wan, W.-L., Li, M.-J., Chang, Y.*, Sung, H.-W.*, “Acidity-triggered charge-convertible nanoparticles that can cause bacterium-specific aggregation in situ to enhance photothermal ablation of focal infection,” Biomaterials, vol. 116, pp. 1–9, 2017. (SCI 11.59) 

  7. Lu, K.-Y., Lin, P.-Y., Chuang, E.-Y., Shih, C.-M., Cheng, T.-M., Lin, T.-Y., Sung, H.-W.*, Mi, F.-L.*, “H2O2-depleting and O2-generating selenium nanoparticles for fluorescence imaging and photodynamic treatment of proinflammatory-activated macrophages,” ACS Applied Materials & Interfaces, vol. 9, pp. 5158–5172, 2017. (SCI 9.229) 

 

2016

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  1. Huang, C.-C., Liao Z.-X., Lu H.-M., Pan, W.-Y., Wan W.-L., Chen C.-C. , Sung, H.-W.*, “Cellular Organelle-Dependent Cytotoxicity of Iron Oxide Na-noparticles and Its Implications for Cancer Diagnosis and Treatment: A Mechanistic Investigation,” Chemistry of Materials, vol. 28, pp. 9017–9025, 2016. (SCI 8.97 ) 

  2. Pan, W.-Y., Lin, K.-J., Huang, C.-C., Chiang, W.-L., Lin, Y.-J., Lin, W.-C., Chuang, E.-Y., Chang, Y.*, Sung, H.-W.*, “Localized sequence-specific release of a chemopreventive agent and an anticancer drug in a time-controllable manner to enhance therapeutic efficacy,” Biomaterials, vol. 101, pp. 241–250, 2016. (SCI 11.59)

  3. Chuang, E.-Y., Lin, C.-C., Chen, K.-J., Wan, D.-H., Lin, K.-J., Ho, Y.-C., Lin, P.-Y., Sung, H.-W.*, “A FRET-guided, NIR-responsive bubble-generating liposomal system for in vivo targeted therapy with spatially and temporally precise controlled release,” Biomaterials, vol. 93, pp. 48–59, 2016. (SCI 11.59)

  4. Huang, C.-C., Chia, W.-T., Chung, M.-F., Lin, K.-J., Hsiao, C.-W., Jin, C., Lim, W.-H., Chen, C.-C., Sung, H.-W.*, “An Implantable Depot That Can Generate Oxygen in Situ for Overcoming Hypoxia-Induced Resistance to Anticancer Drugs in Chemotherapy,” Journal of the American Chemical Society, vol. 138, pp. 5222–5225, 2016. (SCI 15.419)

  5. Lin, C.-W., Lu, K.-Y., Wang, S.-Y., Sung, H.-W.*, Mi, F.-L.*, “CD44-specific nanoparticles for redox-triggered reactive oxygen species production and doxorubicin release,” Acta Biomaterialia, vol. 35, pp. 280–2992, 2016. (SCI 6.383)

  6. Pan, W.-Y., Huang, C.-C., Lin, T.-T., Hu, H.-Y., Lin, W.-C., Li, M.-J.*, Sung, H.-W.*, “Synergistic antibacterial effects of localized heat and oxidative stress caused by hydroxyl radicals mediated by graphene/iron oxide-based nanocomposites,” Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 12, pp. 431–438, 2016. (SCI 6.5)

  7. Huang, C.-C., Pan, W.-Y., Tseng, M.-T., Lin, K.-J., Yang, Y.-P., Tsai, H.-W., Hwang, S.-M., Chang, Y., Wei, H.-J.*, Sung, H.-W.*, “Enhancement of cell adhesion, retention, and survival of HUVEC/cbMSC aggregates that are transplanted in ischemic tissues by concurrent delivery of an antioxidant for therapeutic angiogenesis,” Biomaterials, vol. 74, pp. 53–63, 2016. (SCI 11.59)

 

2015

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  1. Huang, C.-C., Wei, H.-J., Lin, K.-J., Lin, W.-W., Wang, C.-W., Pan, W.-Y., Hwang, S.-M., Chang, Y., Sung, H.-W.*, “Multimodality noninvasive imaging for assessing therapeutic effects of exogenously transplanted cell aggregates capable of angiogenesis on acute myocardial infarction,” Biomaterials, vol. 73, pp. 12–22, 2015. 2015. (This paper has been selected as one of the 3 winners of 2015 Biomaterials Outstanding Paper Award) (SCI  11.59)

  2. Chung, M.-F., Chia, W.-T., Wan, W.-L., Lin, Y.-J., Sung, H.-W.*, “Controlled Release of an Anti-inflammatory Drug Using an Ultrasensitive ROS-Responsive Gas-Generating Carrier for Localized Inflammation Inhibition,” Journal of the American Chemical Society, vol. 137, pp. 12462–12465, 2015. (SCI 15.419)

  3. Chuang, E.-Y., Lin, K.-J., Lin, P.-Y., Chen, H.-L., Wey, S.-P., Mi, F.-L., Hsiao, H.-C., Chen, C.-T.,* Sung, H.-W.*, “Self-assembling bubble carriers for oral protein delivery,” Biomaterials, vol. 64, pp. 115–124, 2015. (SCI 11.59)

  4. Vijayaraghavan, P., Vankayala, R., Chiang, C.-S., Sung, H.-W., Hwang, K.-C.*, “Complete destruction of deep-tissue buried tumors via combination of gene silencing and gold nanoechinus-mediated photodynamic therapy,” Biomaterials, vol. 62, pp. 13–23, 2015. (SCI  11.59)

  5. Chung, M.-F., Liu, H.-Y., Lin, K.-J., Chia, W.-T.,* Sung, H.-W.*, “A pH-responsive carrier system that generates NO bubbles to trigger drug release and reverse P-glycoprotein-mediated multidrug resistance,” Angewandte Chemie International Edition, vol. 54, pp. 9890–9893, 2015. (SCI 12.257)

  6. Mihic, A., Chu, Z., Wu, J., Vlacic, G.,　Ｍiyagi, Y.,　Li, S.-H., Lu, S., Sung, H.-W., Weisel, R.-D, Li, R.-K.*, “A conductive polymer hydrogel supports cell electrical signaling and improves cardiac function after implantation into myocardial infarct,” Circulation, vol.132, pp.772-784, 2015. (SCI 23.054)

  7. Hsiao, C.-W., Chuang, E.-Y., Chen, H.-L., Wan, D.-H., Korupalli, C, Liao, Z.-X., Chiu, Y.-L., Chia, W.-T., Lin, K.-J.,* Sung, H.-W.*, “Photothermal tumor ablation in mice with repeated therapy sessions using NIR-absorbing micellar hydrogels formed in situ,” Biomaterials, vol. 56, pp. 26–35, 2015. (SCI 11.59)

  8. Liao, Z.-X., Chuang, E.-Y., Lin, C.-C., Ho, Y.-C., Lin, K.-J., Cheng, P.-Y., Chen, K.-J., Wei, H.-J., Sung, H.-W.*, “An AS1411 aptamer-conjugated liposomal system containing a bubble-generating agent for tumor-specific chemotherapy that overcomes multidrug resistance” Journal of Controlled Release, vol. 208, pp.42－51, 2015. (SCI 8.66)

  9. Chiang, W.-L., Lin, T.-T., Sureshbabu, R., Chia, W.-T., Hsiao, H.-C., Liu, H.-Y., Yang, C.-M., Sung, H.-W.*, “A rapid drug release system with a NIR light-activated molecular switch for dual-modality photothermal/antibiotic treatments of subcutaneous abscesses,” Journal of Controlled Release, vol. 199, pp.53－62, 2015. (SCI 8.66)

  10. Hsiao, C.-W., Chen, H.-L., Liao, Z.-X., Sureshbabu, R., Hsiao, H.-C., Lin, S.-J., Chang, Y.*, Sung, H.-W.*, “Effective photothermal killing of pathogenic bacteria by using spatially tunable colloidal gels with nano-localized heating sources,” Advanced Functional Materials, vol.25, pp.721−728, 2015. (SCI 18.808)

  11. Priya Vijayaraghavan, Raviraj Vankayala, Chiang, C.-S., Sung, H.-W., Hwang, K.-C.*,“Complete Destruction of Deep Tissue-Buried Tumors via Combination of Gene Silencing and Gold Nanoechinus-Mediated Photodynamic Therapy,”, Biomaterials 2015, 62,13-23. (SCI 11.59)

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